February 13, 2024
2 minute read
Important points:
- Gestational hypertension and gestational diabetes increase the chance of having a child with less than ideal cardiovascular health
- The association became stronger as adverse maternal health indicators increased.
Women with gestational hypertension, gestational diabetes, or both are more likely to have children with worsening CV health 10 to 14 years after giving birth, according to pregnancy conference presenters.
“We know that adverse pregnancy outcomes increase the risk of adverse outcomes for mothers and babies at birth, and our findings suggest that these outcomes may lead to long-term CV health outcomes for mothers. There is a growing body of data that suggests the same may be true for children. But the problem is that these cardiometabolic outcomes don’t affect people until much later in life. This means that it will probably take half a century for children to develop this knowledge.” Kartik Kailash Venkatesh, MD; said Helio, a maternal-fetal medicine subspecialist and assistant professor of obstetrics and gynecology and epidemiology at The Ohio State University. “What we asked was whether there was an association between these adverse pregnancy outcomes and cardiovascular health at the peak of adolescence.”
Venkatesh et al. conducted a secondary analysis of data from 3,317 mother-infant pairs from the Prospective Hyperglycemia and Adverse Pregnancy Outcomes Follow-up Study (HAPO FUS).Researchers assessed the relationship between factors in pregnancy — Hypertensive disorders of pregnancy alone, gestational diabetes alone, and both gestational hypertension and gestational diabetes. — and the health status of the child’s resume. Pediatric CV health factors such as BMI, blood pressure, total cholesterol level, and blood glucose level were categorized as ideal, intermediate, or poor using pediatric guidelines. The researchers also found that by categorizing CV health status based on the number of non-ideal indicators compared to all ideal indicators, exposure was associated with a progressive decline in CV health status. We evaluated the extent to which
The primary endpoint was at least one nonideal CV health measure at ages 10 to 14 years.
Of the cohort, 7.9% of pregnant women developed gestational hypertension, 12.1% developed gestational diabetes, and 2.5% developed both gestational hypertension and gestational diabetes.
At a median age of 11.6 years, 55.5% of children had at least one indicator of less than ideal CV health. In adjusted models, women with gestational hypertension only (adjusted RR = 1.16; 95% CI, 1.04-1.28), gestational diabetes only (aRR = 1.11; 95% CI, 1.02-1.21), and both conditions Female (aRR = 1.17; 95% CI, 1.02-1.21). (95% CI, 1-1.38), women were more likely to have a child with subideal CV health at age 10 to 14 years compared to women without these conditions.
In a secondary analysis, the researchers found that the association became stronger as both the number and severity of adverse CV health indicators increased.
According to Venkatesh, these findings highlight a potential intergenerational cycle of cardiometabolic disease: Adverse pregnancy outcomes can lead to poor CV in children, who in turn suffer from adverse outcomes later in life. are more likely to develop adverse pregnancy outcomes.
“Instead of focusing on the disease, as we have done here, integrating CV health as a framework and thinking early on as something that can strengthen and maintain CV health will help patients and providers… It is truly a magical moment for us,” Venkatesh said. “We can use this as an opportunity. [to] There are meaningful things we can do to strengthen and maintain CV health. It is much better to intervene early than to wait until a disease condition develops. Because by then your options are limited. ”
For more information:
Kartik Kailash Venkatesh, MD; Please contact kartik.venkatesh@osumc.edu.
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