alcohol/drug use
A new study led by Yi Li and Chunyu Liu has identified biomarkers associated with alcohol consumption that suggest that long-term moderate drinking may have an adverse effect on the risk of developing cardiovascular disease.
While past research has shown that moderate alcohol consumption may reduce the risk of cardiovascular disease (CVD), more recent research has shown that moderate levels of alcohol consumption may be dangerous to heart health. It has been suggested that it may have an effect. A new analysis led by Tufts University School of Public Health and Friedman School of Nutritional Science and Policy provides new insights into the complex relationship between alcohol consumption and the progression of CVD.
It was published in the magazine BMC MedicineThe study found that alcohol intake had an adverse effect on CVD risk, depending on the biological presence of certain circulating metabolites (molecules produced during or after the metabolism of substances and studied as biomarkers for many diseases). It was found that it may have an effect.
Researchers observed a total of 60 metabolites associated with alcohol consumption, with seven circulating metabolites linking long-term moderate alcohol consumption to increased risk of CVD, and this same drinking pattern associated with reduced risk of CVD. We identified three circulating metabolites that are associated with
This finding provides a deeper understanding of the molecular pathways of long-term alcohol consumption and calls for and directs further research on these metabolites to inform targeted prevention and treatment of alcohol-related CVD. I’m emphasizing it.
“Study results show that alcohol consumption causes changes in metabolomic profiles, which can have both beneficial and detrimental outcomes,” said Zhangtao Ma, professor of biostatistics at SPH. said Chunyu Liu, co-lead and co-senior author of the study. , assistant professor of nutritional epidemiology and data science at the Friedman School. “As the majority of our study participants are moderate alcohol consumers, our findings contribute to the ongoing debate about the relationship between moderate alcohol intake and heart health.
“Rather than finalizing that debate, however, this study highlights the complex effects of alcohol consumption on cardiovascular health and generates useful hypotheses for future research.” says.
For the study, researchers tested blood samples and measured the cumulative average of beer, wine, and alcoholic beverages among 2,428 participants in the long-running Framingham Heart Study Offspring Study, children of Boston University participants. The association between consumption and 211 metabolites was determined. Framingham Heart Research for over 20 years. Of the participants, 636 developed his CVD during the study period.
Of the 60 drinking-related metabolites, 13 metabolites showed stronger associations with alcohol intake in women than in men. This is probably because women are generally smaller and are more likely to have higher blood alcohol concentrations after consuming the same amount of alcohol as men.
The results also showed that consumption of different types of alcohol was associated with different metabolic responses, with beer consumption showing a slightly weaker association overall than wine or liqueurs. For about two-thirds of the 60 metabolites, higher plasma levels were detected in participants who consumed more alcohol.
Branched-chain amino acids (BCAAs) are one of the metabolites not associated with alcohol intake.
The researchers then calculated two alcohol consumption-related metabolite scores that were inversely associated with the development of CVD.
“While our study presents interesting findings, validation with state-of-the-art methods and a large, diverse research population is critical,” said Marr. “As the current study participants are all Caucasian, we aim to conduct a larger study that includes more diverse racial and ethnic backgrounds to increase reliability. Additionally, genetic information, etc. We will expand our research by integrating with other molecular markers to unravel the complex relationship between alcohol intake, metabolite signatures, and cardiovascular risk.”
The study’s lead author was Yi Li, a doctoral student in the Department of Biostatistics at SPH. This study was funded by the National Institute on Alcohol Abuse and Alcoholism, and data collection for the Framingham Heart Study was supported by the National Heart, Lung, and Blood Institute.
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