1. For multiparous women, experiencing infertility was associated with lower cardiovascular health scores in midlife..
Evidence evaluation level: 2 (good)
research summary: Infertility, defined as the inability to conceive after at least 12 months of unprotected sex, is known to have a significant impact on both physical and mental health. However, the relationship between infertility and cardiovascular health is poorly understood. Researchers aimed to assess whether there is an association between infertility and cardiovascular health in midlife in multiparous women. Participants in this study included 468 women who delivered singleton pregnancies between 1999 and 2002. Follow-up assessments were conducted in participants’ midlife from 2017 to 2021 to collect infertility history and behavioral, biomedical, and reproductive data. and blood biomarkers risk factors for cardiovascular disease. Significant associations were found between infertility and lower cardiovascular health composite, biomedical, and biomarker scores in midlife. No significant association was found between infertility and behavioral risk factors for cardiovascular disease. The results of this study suggest that a history of infertility may be a useful biomarker for future cardiovascular health.
Click to read the full study on JAMA Network Open
detail [prospective cohort]: Through the Project Visa study, 468 multiparous participants were enrolled. Pregnant women with singleton births in Boston, Massachusetts were recruited from 1999 to 2002. From 2017 to 2021, researchers conducted midlife assessments, at which point data on participants’ infertility history was collected. Additionally, the researchers assessed participants’ cardiovascular disease risk factors, including areas of lifestyle, biomedical, and biomarker risk factors. These variables were selected based on the American Heart Association’s Life’s Essential 8 (LE8) and used to generate her score from 0 to 100 to quantify risk factors for a participant’s cardiovascular health. it was done. A higher score indicates better overall cardiovascular health. The mean (SD) age at midlife assessment was 50.6 (5.3) years. 43.2% of participants reported experiencing infertility. The mean (SD) LE8 score was 76.3 (12.2). The mean (SD) scores for the risk factor domains were 76.5 (13.4) for the behavioral domain, 76.0 (17.5) for the biomedical domain, and 78.9 (19.2) for the blood biomarker domain. The researchers adjusted for confounding factors such as age at midlife visit, race, education, income, childhood body size (at age 10), and age at menarche. Overall, those who experienced infertility were found to have lower LE8 scores in midlife, with overall scores 2.94 points lower (95% CI, -5.13 to -0.74 points) and biomedical scores 4.07 points lower. (95% CI, -0.74 points). 7.33 to -0.78 pints), and blood biomarker scores were 5.98 points lower (95% CI, -9.71 to -2.26 points) compared to those who did not experience infertility. No clinically significant association was found between infertility and behavioral domain scores. This study was limited by a relatively small sample size and exclusion of nulliparas, but included a long follow-up period to confirm its power. Similarly, the researchers did not assess the cause of the participants’ infertility, which may have included male-factor infertility. Overall, this study demonstrates an association between infertility and lower global, biomedical, and biomarker scores for midlife cardiovascular health in multiparous women. Further research is needed to determine whether infertility is clinically useful as a risk factor for future cardiovascular health.
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